Theories of Muscular Contraction

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A Distribution-Moment Approximation for Kinetic Theories of Muscular Contraction

A rational mathematical procedure is proposed for approximating solutions to the partial differential equations of cross-bridge kinetics in theories of muscular contraction of the type first proposed by A. F. Huxley. The essence of the procedure is to approximate the exact bond-distribution functions by distributions of prescribed form, and this leads to a set of first-order ordinary differenti...

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The dependence of PC(1) and ATP(1) dephosphorylation on the number of isometric twitches in the iodoacetate-nitrogen-poisoned muscle has been examined. There is no net dephosphorylation of adenosinetriphosphate. PC dephosphorylation varies linearly with the number of twitches and produces equivalent amounts of C(1) and P(1i).(1) Iodoacetate concentrations which block the enzyme, creatine phosph...

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The kinetics of muscular contraction is basic for the quantitative description of muscle and understanding its molecular mechanism. However, the subject has been embarrassed by several historical accidents. First, due to the lack until recently of adequate high (mechanical) impedance transducers, attention was focussed on isotonic measurement; this led to the idea of muscle as a shortening gene...

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The Mechanochemistry of Muscular Contraction

The dependence of PC a and ATP 1 dephosphorylation on the number of isometric twitches in the iodoacetate-nitrogen-poisoned muscle has been examined. There is no net dephosphorylation of adenosinetriphosphate. PC dephosphorylation varies linearly with the number of twitches and produces equivalent amounts of C a and p~.l Iodoacetate concentrations which block the enzyme, creatine phosphokinase,...

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ژورنال

عنوان ژورنال: Nature

سال: 1932

ISSN: 0028-0836,1476-4687

DOI: 10.1038/129165a0